Gonadorelin, also known as Gonadotropin-releasing hormone (GnRH), is a synthetic hormone similar to HCG (human chorionic gonadotropin). Gonadorelin stimulates the release of follicle stimulating hormone (FSH) as well as luteinizing hormone (LH) from the anterior pituitary gland. Commonly used by those who have been on hormone replacement therapy (HRT), or those that use (PEDs) performance enhancing drugs and designer steroids, gonadorelin essentially “tricks” your body into producing more testosterone, helping support fertility, testicular size, and producing anabolic and androgenic effects.

What Is Gonadorelin

Gonadorelin, is a gonadotropin-releasing hormone (GnRH) agonist. It is a synthetic hormone similar to HCG (human chorionic gonadotropin). Studies have shown that gonadorelin, provides several therapeutic benefits, such as improving libido, testicular size, increasing lean muscle mass, and improving testosterone levels.

Gonadorelin is realized in the hypothalamus and stimulates the release of follicle stimulating hormone (FSH) as well as luteinizing hormone (LH) from the anterior pituitary gland.

How Does Gonadorelin Work, What Does Gonadorelin Do

Gonadorelin is a decapeptide, synthesized by the hypothalamus. In humans, the reproductive system is regulated by a process that requires the action of hormones in the hypothalamic–pituitary–gonadal (HPG) axis loop.

The hypothalamic pulsatile secretion of GnRH results in the expression and release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary gland by the adenohypophysis [R, R].

Gonadorelin, is a long acting and potent GnRH, that can help hypothalamic hypogonadal and infertility states in both men and women.

Gonadorelin, stimulates the release of FSH and LH and increases testosterone production. This will also facilitate androgenic and anabolic effects, increasing lean muscle mass, strength, and bone mineral density. LH stimulates Leydig cells in the testicles, which results in the production of testosterone.

Gonadorelin Benefits

May Help Increase Testicular Size

Individuals using PEDs or TRT, often need to also supplement with a GnRH, to help maintain testicular size, fertility, and sperm count. PEDs as well as testosterone may shrink the testicles, thus supplementing with gonadorelin, exerts positive benefit on fertility and improves testicular function.

Studies have shown that gonadorelin, may help increase testicular size, which is beneficial for those that may have hypogonadism [R].

Improves Fertility And Testosterone Production

Testosterone replacement therapy, (TRT) is a commonly used method to boost levels of free form testosterone in the body. However, increasing testosterone can have side effects such as shrinking the gonads and causing infertility. By combining gonadorelin with testosterone, you can therefore, reduce infertility in males with testosterone deficiency, by increasing free levels of testosterone.

TRT and anabolic-androgenic steroids (AAS) can suppress the hypothalamic-pituitary-gonadal (HPG) axis [R].

A large body of evidence suggests that gonadorelin may improve fertility in both men and women. Gonadorelin, increases androgenic activity improving and normalizing sperm count and testosterone levels [R].

Increases Lean Muscle Mass

Lean muscle mass declines as you age, which is directly associated with a fall in hormonal levels. Hundreds of studies have shown that higher levels of testosterone enhance muscle protein synthesis, leading to muscle hypertrophy, gains in strength, and better recovery [R].

Studies have also shown that a combination of GnRH and exogenous testosterone, increases fat free mass, lean mass, and muscle strength [R].

Gonadorelin, increases endogenous testosterone levels. More testosterone stimulates protein synthesis (anabolic effect) and inhibits protein degradation (anti-catabolic effect); combined, these effects lead to the promotion of increased muscle mass and strength [R].

Aging, results in what’s known as anabolic resistance. A reduced acute response to testosterone and to resistance exercise will occur making it more difficult to gain muscle mass overtime. Gonadorelin can help improve the aging process, by improving testosterone levels and muscle protein synthesis.

Gonadorelin Side Effects

Gonadorelin, is generally well tolerated and safe for indicated use. Mild side effects may occur such as

Headache
Stomach or abdominal pain
Diarrhea
Bloating
Pain or redness of injection site
Acne
Breast tenderness

Some women using this medicine have developed a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment cycle. OHSS can be a life-threatening condition. Call your doctor right away if you have any of the following symptoms of OHSS:

severe pelvic pain
swelling of the hands or legs
stomach pain and swelling
shortness of breath
weight gain
diarrhea
nausea or vomiting; or
urinating less than normal.

 Gonadorelin: Takeaway

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